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Quatrefolic® PRO

Introducing Quatrefolic® PRO: SCIENCE meets PERFORMANCE, for your next-generation formulations.

Just as we launched Quatrefolic® Fine Powder, we were finalizing testing for Quatrefolic® PRO—the newest innovation in the Quatrefolic® family. This product is ready to make waves at SupplySide Global 2025, with proven scientific validation that assures its market-readiness. Quatrefolic® PRO takes folate supplementation to the next level, designed specifically to meet the needs of formulators and manufacturers seeking the highest standards in oral bioavailability, flowability, stability, and purity—even in high-humidity environments.

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Market Segments
  • Reproduction & Women’s
  • Wellness & Immune
  • Mobility & Joint
  • Mood & Cognitive
Health Benefits
  • Fertility
  • Pregnancy
  • Menopause
  • Cardiovascular-health
  • Beauty
  • Diabetes
  • Sports Nutrition
  • Mood Health
Allergens and Certificates
  • Gluten-free
  • Halal
  • Kosher
  • Non GMO
  • Vegetarian
  • Vegan

The Future of Folate Supplementation 

With Quatrefolic®, Gnosis by Lesaffre continues to push the boundaries of innovation in nutritional supplements. Whether you’re looking for superior bioavailability in 5-MTHF glucosamine salt, the versatility of Fine Powder for liquid formulations, or the stable consistency of Quatrefolic® PRO, we have the perfect solution to elevate your folate supplementation offerings.

 

Consistency in Dosage & Optimal Formulation

Quatrefolic® PRO is packed with benefits that make it the ideal choice for supplement formulation. By ensuring the correct amount of active folate in every tablet or capsule, Quatrefolic® PRO guarantees uniformity in the final product. Variations in powder density are minimized, ensuring consistent active ingredient distribution. Thanks to its superior flowability, Quatrefolic® PRO enables easy capsule filling and compression for tablet formation. This results in better manufacturing processes and more efficient production cycles. 

 

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Quality Control & Reduced Production Costs

With its tightly controlled bulk and tapped density, Quatrefolic® PRO provides essential data to ensure consistent product quality from batch to batch. This data helps manufacturers avoid issues such as fluctuations in moisture content or particle size variation, leading to more reliable, stable products. Manufacturers can reduce overall production costs by optimizing the compaction process and minimizing waste. Understanding tapped density helps streamline the manufacturing process, maximizing the efficient use of materials and reducing unnecessary wastes.

Mature scientist looking in microscope during chemical investigation Quatrefolic® PRO in lab

Proven Performance

Quatrefolic® PRO’s benefits are not just theoretical—extensive testing has confirmed its exceptional properties. According to European and American Pharmacopoeia guidelines, Quatrefolic® PRO is classified as “very soluble,” ensuring quick absorption and bioavailability in a wide variety of supplement formulations. Low water activity and reduced loss on drying make Quatrefolic® PRO more compatible with other nutrients, ensuring a more stable, well-balanced final product. Quatrefolic® PRO’s enhanced flow makes mixing easier and improves uniformity in the final product, reducing processing time and increasing overall manufacturing efficiency.

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What is Folate?

Folate, also known as vitamin B9 or folic acid, is a water-soluble essential nutrient that plays a crucial role in many physiological processes in the body, such as healthy cell growth, DNA synthesis, and red blood cell formation.

Deep dive into all Quatrefolic® has to offer by visiting our product site.

What is Folate?