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Adonat® is the leading brand of S-Adenosyl-L-methionine (SAMe), a compound produced naturally by the body that is required for proper brain functioning. SAMe is involved in more than one hundred biochemical pathways and it has been shown to have benefits for the mood, liver, joints, and more.



The body requires quantities of SAMe that the diet cannot provide alone, and decreased or low SAMe levels in some biological fluids and tissues are connected with altered body states such as depression. The result of more than 30 years of expertise and 10 patents, Adonat combines state-of-the-art industrial manufacturing, relentless innovation, and esteemed research to achieve a proprietary stabilized salts and  innovative forms of oral dosage.

Market segments for Adonat:

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An expertise that guarantees quality
The quality level of SAMe dietary ingredient is the key to have an effective and reliable finished product on the market. Adonat® offers the highest content of biologically active SAMe, with an (S,S) isomer content ≥ 75 % , where the USP Dietary Supplement Monograph” requires only ≥ 60.0 %), for a certain efficacy and safety and a reliable experience of dietary supplement manufacturers and final consumers.
The pharmaceutical grade SAMe
Gnosis by Lesaffre is the worldwide key manufacturing of SAMe pharmaceutical grade (AATC Code "Alimentary Tract and Metabolism": A16AA02) produced in the approved pharmaceutical plant where well-trained staff guarantee highest quality in strict compliance with CGMP requirements.
A consolidated manufacturing process and supply chain
Pharmaceutical cGMP rules are applied to both pharmaceutical and nutraceutical production lines. All manufacturing steps respect and protect the active ingredient as well as the entire supply chain, which is strictly controlled and consistently optimized with periodic activities.
Exclusive and flexible dosage forms
We perpetually continues our R&A development for products made with SAMe, and today we are the only manufacturer in the world able to supply high quality SAMe bulk powder, enteric coated tablets, mixes, and stabilized oral dosage forms – for both nutritional and pharmaceutical applications.
The first to market in SAMe
Gnosis by Lesaffre was the first company to introduce and commercialize SAMe in the worldwide market. Today, its cGMP-approved manufacturing plant in Switzerland guarantees the highest quality standards.
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From the worldwide leading producer of SAMe

Adonat is produced by a biotransformation process of Saccharomyces cerevisiae yeast cultures and is purified without the use of solvents.

Non-GMO

Lactose
Free

Gluten
Free

Kosher

Halal

Bring the benefits of Adonat to your application.

Get in touch with Gnosis by Lesaffre today to commence your next product innovation.

Mood & Cognitive Health