The S-adenosyl-L-methionine (SAMe) can be a versatile molecule in alleviating various symptoms associated with menopause, from hot flashes and mood changes to bone– and heart–health concerns.
As women navigate the menopausal transition, they often seek natural and effective solutions to address the diverse range of symptoms and long-term health concerns.
S-adenosyl-L-methionine (SAMe), an endogenous compound found naturally in the body, has emerged as a promising ally in promoting whole-body wellness during this life stage.
Menopause is a difficult transition for a woman. In addition to coping with hot flashes and impaired memory performance, this time of significant change also heightens mood impairments, with which women struggle personally, but is amplified by a possible negative perception of them.
SAMe plays a crucial role in numerous biochemical pathways, serving as a methyl group donor and contributing to synthesizing important neurotransmitters like serotonin, dopamine, and norepinephrine. These functions make SAMe a good candidate for addressing the hormonal and neurochemical imbalances that often accompany the menopausal transition.
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Clinical studies have explored the use of SAMe in managing vasomotor symptoms, such as hot flashes and migraines, as well as mood-related issues like depression and anxiety. While the level of clinical evidence varies, the available data suggests that SAMe may help regulate the thermoregulatory system and neurotransmitter balance, potentially providing relief for menopausal women.
Beyond its benefits for immediate symptoms, researchers have also investigated SAMe for its potential to support long-term health concerns associated with menopause, such as increased cardiovascular risks and compromised bone health. By influencing key metabolic pathways, SAMe may help maintain healthy cholesterol levels, reduce inflammation, and support bone remodeling, offering a multifaceted approach to addressing the long-term consequences of estrogen decline.
Adonat®: A Recognized Brand for Premium Quality and Effectiveness
With the rise of e-commerce and global market commercialization of dietary ingredients, the quality and stability of the raw materials offered are becoming even more critical. Adonat® Premium SAMe is the only registered brand of SAMe in the worldwide market. It assures quality and effectiveness through a flexible portfolio of bulk and tablet options.
Gnosis by Lesaffre’s deep assessment goes beyond standard analysis, supporting Adonat® Premium SAMe’s position as a brand that provides consumers with efficient and safe supplements to meet their health and wellness needs. From mood and cognitive health to liver detoxification, joint health, longevity, and stamina, our solutions provide extensive opportunities for SAMe formulations to cover several health benefits.
Read more in the flier released about Adonat® and Menopause.
Ingredients mentioned

Adonat® Preformulated Bulk Powders
Active ingredients
SAMe (S-adenosyl-L-methionine): We offer unique and flexible stabilized forms (powder and granules) suitable to be formulated in blends and combinations for exclusive market solutions. Adonat® Stabilized Powder is the only suitable SAMe powder that can be formulated in capsules as a standalone or in combination with other active substances.
Mood & Cognitive
Mobility & Joint
Digestion & Gut
Mood
Cognition
Stress & Anxiety

Adonat® Tablets
Active ingredients
SAMe (S-adenosyl-L-methionine): We offer an exclusive and wide range of SAMe tablets available in two different proprietary coatings, ENTERIC-COATING and ESSENTIAL-COATING, that fully meet the needs of our customers and the market, availble in 200 and 400 mg dosages.
Mood & Cognitive
Mobility & Joint
Digestion & Gut
Mood
Cognition
Stress & Anxiety

Adonat®
Active ingredients
SAMe (S-adenosyl-L-methionine): The leading brand of S-Adenosyl-L-methionine (SAMe), a compound produced naturally by the body that is required for proper brain functioning. SAMe is involved in more than one hundred biochemical pathways and it has been shown to have benefits for the mood, liver, joints, and more.
Mood & Cognitive
Mobility & Joint
Digestion & Gut
Mood
Cognition
Stress & Anxiety
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