Extrafolate-S® is the calcium salt of (6S)-5-methyltetrahydrofolate, and it is intended for use as an alternative to folic acid in dietary supplements, foods for particular nutritional purposes and regular foods.

Extrafolate-S® is the essential active form in which natural folates enter the human circulation, providing higher bioavailability and avoiding concerns about the interaction between vitamin B12 and folic acid supplementation responsible for masking symptoms of vitamin B12 deficiency.

  • Product category
  • Active ingredients
  • Market segments
    • Mobility & Joint
    • Mood & Cognitive
    • Reproduction & Women’s
    • Wellness & Immune
  • Health benefits
    • Cardiovascular-health iconCardiovascular
    • Cognition iconCognition
    • Fertility iconFertility
    • General-Wellbeing iconGeneral Wellbeing
    • Menopause iconMenopause
    • Mood Health iconMood
    • PregnancyPregnancy
    • Sports Nutrition iconSports Nutrition
  • Allergens and
  • Gluten-free
  • Halal
  • Kosher
  • Lactose-free
  • Non GMO

Giving formulators maximum flexibility and versatility for the best quality finished products​

Quatreflora is manufactured under Good Manufacturing Practices (cGMP) and is a certified Active Pharmaceutical Ingredient (API) for use in over-the-counter and prescription products.

A bioactive alternative to folic acid​

Extrafolate-S® contributes to normal maternal tissue growth during pregnancy, homocysteine metabolism, psychological function, amino acid and blood cell synthesis, and function of the immune system.

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Frequently asked questions

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