The Intestine-On-Chip
Probiotics are now considered as key ingredients. To demonstrate their benefits, some scientific models are available. Gnosis by Lesaffre, has developed a new scientific method: the intestine-on-chip.
Gnosis by Lesaffre as a pioneer in innovation wants to invent the science of tomorrow. We develop new models, in order to:
- Innovate better & faster
- Adapt our science to be more and more sustainable
- Mimic as close as possible human model in preclinical stage
- Develop new analytical methods
Current preclinical models show failure rates for probiotics. To overpass these limits, Gnosis by Lesaffre developed with Emulate: the intestine-on-chip model.
A Dynamic in Vitro Model
The technology consists of recreating cellular microenvironments with 3D human-derived cells. Moreover, this model reproduces the microcellular environment. The asset of this model is the dynamic flows on the top channel and bottom channel. These flows and cellular organization mimic a real human environment.
LifeinU™ BSCU1
To validate this new dynamic model in the field of immune response, we have used our well-studied probiotic LifeinU™ BSCU1 (Bacillus subtilis strain CNCM I-2745). LifeinU™ BSCU1 is a stable probiotic dedicated to immunity.
Thanks to its stability, the microorganism is suitable for long shelf-life applications such as functional foods and food supplements.
Deep Dive Into Probiotics
Curious about how probiotic bacteria in your gut can impact your digestion and immune health? Find out more in this article to uncover the amazing benefits of these tiny microorganisms for your well-being.
