Welcome to this exclusive interview with Prof. Andrea Fuso, Ph.D., a prominent scientist who will delve into the fascinating world of epigenetics, shedding light on the pivotal mechanisms that govern gene expression regulation and how they can impact the quality and duration of our lives. So, let’s begin our conversation:
As the global population ages, interest in promoting health and extending lifespan increases. Epigenetic science provides a window into the molecular mechanisms that underlie aging. By studying epigenetic changes, scientists can gain valuable insights into how and why our cells age, which can inform strategies to slow down or even reverse the aging process.
How can Epigenetics be easily described, and how can environmental factors, such as diet, stress, and behavior, influence gene activity, impacting our health and aging?
Imagine our DNA as a library of books, with each book representing a gene. The words in these books are the genetic code and remain constant throughout our lives. However, the epigenetic marks are like bookmarks, highlights, or notes in the margins of these books. They determine which pages are read, how often, and in what order. Although science is moving fast and many factors are still to be better understood and characterized, we already know that some environmental factors influence these processes and impact how we age. Diet, stressors, lifestyle choices, and even social factors are among them.
For instance, certain nutrients in our diet, like folate and methyl groups, play a role in DNA methylation…
Current scientific evidence suggests that the methyl-donor S-Adenosyl-Methionine (like Adonat® Premium SAMe) has a key role in epigenetics regulations and modifications.
What are these key epigenetic mechanisms, and how can SAMe supplementation be an ally and mitigate age-related epigenetic changes?
S-Adenosyl-Methionine (SAMe) is indeed an essential molecule in epigenetic regulation and modifications. It plays a critical role in several key epigenetic mechanisms, and its supplementation has been explored as a potential ally in mitigating age-related epigenetic changes.
As a methyl donor, SAMe can provide these methyl groups to several epigenetic targets such as DNA and histones, which, if we return to the book metaphor, would be the shelves on which…