An innovative scientific model with LifeinU® BSCU1 - Gnosis by Lesaffre

An innovative scientific model with LifeinU® BSCU1

  • LifeinU® BSCU1• Science• Wellness & Immune

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The world is in a constant evolution. This evolution has an impact on the way consumers consider products or services. These changes also concern the science.

Consumers want products that are in line with their values. These values are animal-welfare, sustainability, transparence… These concerns are not only for products but also all that revolves around. People also pay attention to the way science is designed.

Gnosis by lesaffre as pioneer in innovation

Gnosis by Lesaffre, as innovative player in the dietary supplements market, wants to develop the science of tomorrow. We develop new in-vitro models to:
  • Innovate better and faster
  • Adapt our science to be more and more sustainable
  • Mimic as close as possible human model in preclinical stage
  • Develop new analytical methods

To innovate better and faster, we want to develop models that can be suitable for different ingredients or molecules. Using the same model for different ingredient will allow scientific to save time.

To improve the sustainability of science, Gnosis by Lesaffre develops models without animal. Indeed, animal models present lack of translation to clinical study.

Some models are not predictive in human as they are too far for human model in preclinical stage. For example, 2D cell line cultures are too simplistic and not react to a relevant manner compared to human. Some other models such as organoid suspension culture are not suitable to investigate on molecules or ingredients properties such as probiotics.

The intestine-chip revolutionizes the world of in-vitro models

Intestine-chip, also called gut-on-chip, is an innovative in-vitro model develop by Emulate. This stimulating in-vitro model is a dynamic way to investigate on probiotics’ properties. This model is a 3D human-derived cell culture system​. Some cells from the intestine are collected in a human donor. This model is composed by three different parts:
  • A top channel that represents the lumen of the intestine. In this part, the epithelium cells are organized like in human with the villosities on the top. As the organization is like in human, the tight junctions between epithelial cells are located as the same place in human.
  • A bottom channel presenting some endothelial cells. These endothelial cells present a blood vessel organization.
  • A porous membrane between the top and bottom channels. This porous membrane allows the exchange between the two channels as it happens in the human body.
Capture-decran-2022-11-15-a-12.23.37
To validate the robustness of this model, Gnosis by Lesaffre investigate on LifeinU® BSCU1 properties. The efficiency of this probiotic is already validated by a clinical study.
The result of the clinical study highlighted some benefits on immunity. A supplementation with LifeinU® BSCU1 is associated with an increased concentration of the secretory immunoglobulin A (sIgA). sIgA are important antibodies of the immune system. They are considered as the first line of body defense as they can catch toxins and pathogen agents and prevent their interaction with human body. To validate the solidity of the intestine-chip model, LifeinU® BSCU1 was incubated during several hours. After an incubation with LifeinU® BSCU1, the results highlight that the sIgA levels are higher with LifeinU® BSCU1 alone and with LifeinU® BSCU1 with PBMC.
time-after-inoculation
Thanks to these results, we can confirm that the intestine-chip model can be consider as a relevant option to investigate on ingredients or molecules on a preclinical stage.

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