Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid. 

Developed by Gnosis By Lesaffre it represents the fourth generation folate compared to 5-methyltetrahydrofolate calcium salt guaranteeing an improved bioavailability.

Discover Quatrefolic.com
  • Product category
  • Active ingredients
  • Market segments
    • Reproduction & Women’s
    • Wellness & Immune
    • Mobility & Joint
    • Mood & Cognitive
  • Health benefits
    • Fertility iconFertility
    • PregnancyPregnancy
    • Menopause iconMenopause
    • Mood Health iconMood
    • General-Wellbeing iconGeneral Wellbeing
    • Cardiovascular-health iconCardiovascular
    • Cognition iconCognition
    • Sports Nutrition iconSports Nutrition
  • Allergens and
  • Gluten-free
  • Halal
  • Kosher
  • Lactose-free
  • Non GMO

Quatrefolic®: flexibility and versatility for the best quality finished products

Quatrefolic® has a trifecta of functional benefits for formulators: easy handling, room stability and high water solubility.

Know more about Quatrefolic® and its benefits for human health through the dedicated website: quatrefolic.com



Maintain the adequate dietary intake of folate

Quatrefolic® helps maintain sufficient levels of folate, lowering the risk of neural tube defects (NTDs), anemia, various forms of cardiovascular diseases, Alzheimer’s disease, and osteoporosis.


Everyone can benefit

Quatrefolic® provides the metabolic reduced folate form utilized and stored in the human body, the (6S)-5-methyltetrahydrofolate and it does not aid to the potential accumulation of UMFA in the blood.

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Frequently asked questions

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