A trusted source with confirmed efficacy
Adequate folate levels are critical for a healthy pregnancy, and Quatrefolic®, the glucosamine salt of (6S)-5 methyltetrahydrofolate, is the biologically active reduced folate that supports the well-being of the mother and the developing fetus.
Quatrefolic® has been rigorously tested and validated by Gnosis by Lesaffre for safety and consistency.
- GRAS Recognition: Quatrefolic® is “Generally Recognized as Safe” for use as a source of folate in conventional and medical foods.
- FDA New Dietary Ingredient Notification: Quatrefolic® is a trusted source of the naturally occurring form of folate for dietary supplements.
- Scientifically Proven: Clinical studies and scientific research on 5-MTHF confirm the efficacy of Quatrefolic® during pregnancy.
By providing the essential folate needed throughout this critical life stage, Quatrefolic® can help reduce the risk of congenital disabilities, support healthy neural tube development, lower the risk of neural tube defects, and promote the overall well-being of both mother and child.
In a series of clinical studies involving over 1,000 pregnant women, oral supplementation with Quatrefolic® has demonstrated a strong safety profile and efficacy in increasing blood folate levels and avoiding adverse pregnancy outcomes. While many supplements rely on synthetic folic acid, which must be converted in the body to active folate, Quatrefolic® delivers active folate to help support the full benefits of supplementation.
Use and dosage should be discussed with a healthcare practitioner, and dietary supplements are not intended to diagnose, treat, cure, or prevent any health condition.
Deep dive into folate supplementation
Folate, also known as vitamin B9, is a water-soluble essential nutrient that plays a crucial role in many physiological processes in the body, such as healthy cell growth, DNA synthesis, and red blood cell formation.
It should be noted that food folate and synthetic folic acid follow different pathways in the body. The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a key role in the conversion to methyltetrahydrofolate (5-MTHF), the active form. Some people have polymorphic forms of the enzyme MTHFR, making it harder to convert folic acid or food folate efficiently. This can affect homocysteine levels and is linked to increased risk during pregnancy, including recurrent pregnancy loss, preeclampsia, low birth weight, and neural tube defects, especially when sufficient amounts are not obtained through diet or fortified foods alone.
