Quatrefolic® and fertility problems? What new science says


The effect of Quatrefolic® supplementation (400 µg/day plus vit B12 and B6) has been investigated in a retrospective study on pregnancy outcomes in infertile women undergoing ART, versus only folic acid.

Folate and vitamin B12, and the possible increased serum homocysteine (hyperhomocysteinemia, HHcy) – resulting by the shortage of these vitamins – are a very interesting investigation target for pre-conceptional health.

HHcy is believed to have important embryotoxic effects and adverse obstetric/neonatal outcomes.

Quatrefolic® and the higher chance of positive pregnancy outcomes

According to the new study just published by Cirillo et al. women undergoing Assisted Reproductive Treatments (ART) supplemented with vitamin B complex (5-methyltetrahydrofolate as Quatrefolic® plus vitamins B12 and B6 – Normocis® commercialized by the Italian company Inpha Duemila Srl) – have a higher chance of clinical pregnancy and live birth in comparison with those with only folic acid.

To know more about the study published, the people involved, the endpoints, and the findings reached, see the dedicated press release in the Quatrefolic® website.