Active Folate and MTHFR Polymorphism
Folate, also known as vitamin B9, is an essential nutrient that plays a crucial role in numerous bodily functions, from cell growth and development to DNA synthesis. However, for individuals with genetic variations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, the benefits of folate can be significantly impaired.
5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in the biosynthesis of an active folate form.
Genetic polymorphisms in the MTHFR gene, such as the C677T and A1298C variants, can reduce the enzyme’s activity, leading to the accumulation of homocysteine in the body.
Elevated homocysteine levels have been linked to a range of health concerns, including cardiovascular disease, neurological disorders, and pregnancy complications.
This is where the advantages of active folate, such as Quatrefolic®, come into play.
Watch the video and discover how Quatrefolic®/ can bypass the MTHFR conversion step and deliver a «finished» folate the body can immediately use without any metabolization.
Latest news & videos

- News
- Quatrefolic®
- Wellness & Immune
- Jun 12, 2025
Webinar Rethinking Women’s Health 24 June 2025
Women's health is complex, constantly evolving, and a broader perspective is long overdue, one...

- News
- Quatrefolic®
- Wellness & Immune
- Jun 09, 2025
Gnosis by Lesaffre Highlights Quatrefolic® at New Nutrition Forum in Hangzhou, China
Gnosis by Lesaffre was proud to serve as the Title Sponsor of the New...

- Corporate
- Digestion & Gut
- News
- Jun 06, 2025
Biotic Live: A Successful First Edition Exploring the Power of Probiotic Yeasts
Gnosis by Lesaffre recently hosted the first edition of Biotic Live, a unique event...