A new 6-month trial exploring Vitamin K2’s potential to impact calcification in the brain could present a therapeutic option for migraine sufferers.
The World Health Organization (WHO) ranks migraine as the fifth highest cause of years lost due to disability, with approximately 38% of migraine patients requiring preventative therapy. Unfortunately, therapies currently available, which are not migraine-specific, offer limited effectiveness and significant adverse effects.
After a 2019 cross-sectional study presented positive evidence that vitamin K2 was a potential therapy based on its impact on arterial stiffness, Lebanese researchers have initiated a new six-month, randomized, double-blinded, placebo-controlled study, “Efficacy of K2 Supplementation in Adult Episodic Migraine.” Migraine patients between 18 and 45 years of age will be recruited from the neurology clinic at the Lebanese American University Medical Center-Rizk Hospital, Lebanon, with the purpose of testing if vitamin K2 supplementation might “prevent” migraine attacks, as well as testing the impact of vitamin K2 supplementation on arterial stiffness in this group of patients.
“Several mechanisms have been suggested to explain the condition and its linkage to other comorbidities, including generalized anxiety disorders, chronic pain syndromes, and more serious cardiovascular diseases, but studies have failed to explain with certainty the increased cardiovascular risk and reasons behind augmented large arterial stiffness in patients with migraine,” explains lead researcher Sola Aoun Bahous, MD, PhD, MHPE, Dean and Professor of Medicine at Gilbert & Rose-Marie Chagoury School of Medicine, Lebanese American University.
“Vitamin K2 is a fat-soluble vitamin that serves as an essential cofactor in the activation of matrix Gla protein (MGP) in the vascular smooth muscle cell, with vitamin K deficiency resulting in impaired MGP carboxylation and, subsequently, an increased calcification effect,” she continues. “Circulating concentrations of dephosphorylated uncarboxylated MGP (dp-ucMGP) are indicative of vitamin K deficiency and associated with the extent of vascular calcification, arterial stiffness, and development of cardiovascular events in specific populations.”
Earlier Efforts Yield Promising Results
Headache published a previous study where Dr. Aoun Bahous and her colleagues hypothesized that patients with migraine have higher arterial stiffness and lower vitamin K2 levels than those without migraines, with a possible association between the two markers. Patients with migraine had significantly higher arterial stiffness and increased levels of serum dp-ucMGP, reflecting vitamin K2 deficiency, when compared with controls.
“Our  study presented a plausible hypothesis that vitamin K2 deficiency in patients with migraine with aura may contribute to the increased cardiovascular risk observed in this patient population,” she continues. “Furthermore, patients with migraine in general have more vitamin K2 deficiency than their matched controls. With this new study, we hope to explore whether supplementation with vitamin K2 confers cardiovascular protection and reduces migraine episodes.”
A New Approach, Endpoints
“This new study presents a new wave of insight for migraine sufferers, and Gnosis is excited to play a role in these efforts,” says Sophie Legrain-Raspaud, Gnosis by Lesaffre Director of R&A. “Our research has identified and demonstrated the cardio-protective mechanism of vitamin K2, and new research is beginning to surface linking this mechanism to having an impact beyond just heart health, including brain and vision support. We share the researchers’ enthusiasm that this new study could present strong grounds for discussing this potential relationship with migraine patients to guide their dietary habits or supplementation routines toward improving their vitamin K2 status.”
“We have seen the benefits of MenaQ7 on vascular stiffness since we launched it in the market in 2010,” adds Hisham Ramadan, CEO of Omicron. “We have no doubt that MenaQ7 will help migraine patients since they fall under the same category. MenaQ7 has been shown to reduce arterial stiffness significantly, as well as it help substantially those patients who suffered from aortic valve calcification (AVC), coronary artery calcification (CAC), and chronic kidney disease (CKD).