A very recent publication of Clement et al. has recommended that couples with a long history of infertility should be analysed for Methylenetetrahydrofolate Reductase (MTHFR) polymorphism and homocysteine.
Reducing Blood Homocysteine Levels
The group tested blood homocysteine (Hcy) level before and after treatment with Quatrefolic®to control the efficacy of the treatment before starting Assisted Reproductive Technology (ART) attempts.
In the 89 couples included – 50 were heterozygous for the MTHFR polymorphism, 39 homozygous – Quatrefolic® reduced rapidly the Hcy level of 42.7% in homozygous and 20.1% in heterozygous subjects, with no significant difference (p = 0.12) between the normalized Hcy level of homozygous and heterozygous (10.5 mmol/L vs. 9.8 mmol/L).
The Positive Effect of Quatrefolic®
The positive effect of Quatrefolic® (400 µg plus B6 and B12) in lowering and normalizing homocysteine has been also evaluated versus conventional supplementation of high dose of folic acid (5 mg/day) in hypertensive subjects at low cardiovascular risk. Quatrefolic® treatment was more effective in reducing homocysteine serum level than folic acid, normalizing homocysteine in 55.8% of cases, significantly higher than in the control one.
References
- Mazza A, Cicero AF, Ramazzina E, Lenti S, Schiavon L, Casiglia E, Gussoni G. Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. J Biol Regul Homeost Agents. 2016.
- Clément A, Menezo Y, Cohen M, Cornet D, Clément P. 5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility. J Gynecol Obstet Hum Reprod. 2020
Discover Quatrefolic®
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid.
Developed by Gnosis By Lesaffre, it represents the fourth-generation folate compared to 5-methyltetrahydrofolate calcium salt, guaranteeing improved bioavailability.
