
Although the benefits of folate are well-known, the variety of the forms remains unfamiliar for most. After highlighting the notable differences between folic acid and the active form of folate, Quatrefolic® returns with a second infographic comparing the characteristics of the two forms of active folate Calcium salt and Glucosamine salt.
Historically, the folate market has opposed folic acid and active folate, with the development of two active folate salts, like calcium or glucosamine salts. The glucosamine one is patented and produced by Gnosis by Lesaffre and today is known as Quatrefolic®.
With its new infographic, Quatrefolic® presents the features that allow differentiating the two forms.
QUATREFOLIC®, THE RIGHT CHOICE OF FOLATE
The active form of folate is the right choice when it comes to folate. Indeed, Quatrefolic®, 5-MTHF, is the biological active form of folate in plasma and does not require activation, as it happens for food folates and folic acid.
DISCOVER ALL OUR LATEST NEWS

Webinar Rethinking Women’s Health 24 June 2025
Women’s health is complex, constantly evolving, and a broader perspective is long overdue, one that goes beyond reproductive care to include mental health, chronic conditions, and the unique ways diseases manifest in women.

Gnosis by Lesaffre Highlights Quatrefolic® at New Nutrition Forum in Hangzhou, China
Gnosis by Lesaffre was proud to serve as the Title Sponsor of the New Nutrition Forum held in Hangzhou on June 6, 2025. As part of the event’s scientific agenda, we hosted an engaging seminar focused on Quatrefolic®, the 4th generation active folate.

Biotic Live: A Successful First Edition Exploring the Power of Probiotic Yeasts
Gnosis by Lesaffre recently hosted the first edition of Biotic Live, a unique event dedicated to exploring the potential of probiotic yeasts. This live session brought together leading experts to present the latest scientific insights and real-world applications of live yeasts in human health.