What is Salidroside?
Salidroside is a primary active compound naturally found in the roots of Rhodiola rosea, an adaptogenic herb used in traditional medicine.
Salidroside: A powerhouse compound for optimal health and performance
Salidroside has been studied for its potential antioxidant, anti-inflammatory, and neuroprotective properties, with growing interest around its cell-protective profile. It is believed to help the body adapt to stress which is why it is featured in an increasing number of dietary supplements and functional products aimed at supporting cognitive function, cardiovascular health, and overall well-being.
While present in low concentrations in the plant, Gnosis’ innovative fermentation process obtains 98% pure and consistent salidroside for nutraceutical and sports nutrition purposes.
What is salidroside?
What role does salidroside play in traditional medicine and human health?
Salidroside is a bioactive compound primarily extracted from the roots of Rhodiola rosea, a traditional adaptogenic herb, and it is one of the plant’s key active components. As an adaptogen, salidroside is believed to help the body adapt to various forms of stress by modulating the activity of the hypothalamic-pituitary-adrenal (HPA) axis. This can help mitigate the negative effects of stress, such as increased inflammation and oxidative stress.
Salidroside has also demonstrated potential neuroprotective properties, suggesting it may help protect the brain from the damaging effects of oxidative stress and inflammation, which are linked to neurodegenerative conditions. Additionally, research indicates salidroside may offer cardiovascular benefits by improving endothelial function, normalizing blood pressure, and lowering the risk of arterial stiffening. Research has also explored the molecular mechanisms and signaling pathways behind these effects.
While the exact mechanisms are not fully understood, the available evidence suggests salidroside plays a significant role in supporting overall human health and well-being, particularly in stress management, cognitive function, and cardiovascular health, and may also influence multiple systems in the human body.
Our Salidroside Range
LANDKIND® Pure Salidroside
Our innovative fermentation process bypasses the need to harvest the endangered Rhodiola species, producing only Pure Salidroside. It also helps avoid added pressure on wild Rhodiola plants. Crafted through fermentation, LANDKIND® Pure Salidroside provides a sustainable source of Rhodiola’s active component, aligning with rising consumer demand for traceable, sustainable ingredients and offering consistent purity while being inherently CITES compliant.
Why is salidroside so important?
As an adaptogen, salidroside plays a crucial role in helping the body adapt to various forms of stress by modulating the hypothalamic-pituitary-adrenal (HPA) axis, the body’s main stress response system. Its therapeutic potential is drawing interest because it appears to act through several biological processes rather than a single pathway.
Beyond its adaptogenic properties, salidroside exhibits potent antioxidant and anti-inflammatory activities that can help protect cells and tissues from damage.
Further, salidroside has demonstrated promising cardiovascular effects, including improving endothelial function, helping manage blood pressure, and inhibiting the development of arterial stiffness. These actions can reduce the risk of cardiovascular damage and support the cardiovascular system, making salidroside a valuable supplement for heart health.
Given its multifaceted benefits, salidroside has become an increasingly sought-after compound in the natural health market, particularly for its potential applications in stress management, cognitive function, and overall well-being.
How does salidroside work?
Salidroside is believed to exert its beneficial effects through several underlying molecular mechanisms. As previously mentioned, salidroside has been suggested to help the body adapt to various forms of stress by modulating the activity of the hypothalamic-pituitary-adrenal (HPA) axis, the body’s main stress response system.
By regulating the HPA axis, salidroside may help mitigate the negative consequences of chronic stress, such as increased inflammation and oxidative stress.
These anti-inflammatory and antioxidant activities have been observed in numerous studies, suggesting that it may help protect cells and tissues from damage and improve cell survival under stress conditions.
Furthermore, salidroside has been shown to improve endothelial function, reduce blood pressure, and inhibit arterial stiffening, potentially contributing to its cardioprotective effects.
Preclinical research has also examined its protective effects from reactive oxygen species, cell apoptosis, and the inflammatory response. While the exact mechanisms are not fully elucidated, the multifaceted actions of salidroside, including its adaptogenic, antioxidant, anti-inflammatory, and neuroprotective properties, suggest it may play a significant role in supporting overall health and well-being.
Is Rhodiola rosea the same as LANDKIND® Pure Salidroside?
Rhodiola and LANDKIND® Pure Salidroside are not exactly the same. Salidroside is the bioactive compound found in the Rhodiola rosea plant, while LANDKIND® Pure Salidroside refers to Gnosis’ active ingredient of just pure salidroside.
LANDKIND® Pure Salidroside is produced through an innovative and sustainable fermentation process, offering a consistent, high-quality source of pure salidroside.
Furthermore, LANDKIND® Pure Salidroside is supported by a clinical study. It was one of the first clinical studies on fermentation-derived salidroside for performance-related outcomes, evaluating the short-term effects of supplementation on exercise performance and mood state.
Positive results have been found, demonstrating that LANDKIND® Pure Salidroside may:
- Enhance oxygen uptake during exercise
- Mitigate mood disturbances, particularly in areas of fatigue-related inertia and friendliness
- Help inhibit performance deficits due to accumulated fatigue.
More than 720 scientific papers, including 22 reviews, support the use of salidroside as a stand-alone ingredient. This evidence base includes preclinical and in vivo studies, as well as emerging human data. The above-mentioned clinical study is the first of its kind and confirms its interest as an important bioactive of Rhodiola in sports nutrition. That’s why Salidroside is the go-to ingredient in sports nutrition.
Salidroside quick facts
- Source: Salidroside is primarily extracted from the roots of Rhodiola rosea, also known as golden root or arctic root, as well as other selected Rhodiola spp.
- Adaptogenic properties: Salidroside helps the body adapt to various forms of physical, mental, and emotional stress.
- Anti-inflammatory and antioxidant effects: Salidroside has demonstrated potent anti-inflammatory and antioxidant activities, which may protect cells and tissues from damage.
- Neuroprotective potential: Research suggests salidroside may help protect the brain by reducing oxidative stress, neuroinflammation, and cell death.
- Cardiovascular benefits: Salidroside may improve endothelial function, help manage blood pressure, and inhibit arterial stiffening, potentially reducing the risk of compromised cardiovascular function.
- Standardized extracts: Rhodiola rosea contains relatively low concentrations of salidroside and other secondary metabolites, so standardized extracts or Gnosis’s fermentation process allow higher and more consistent doses.
- Versatile applications: Salidroside supplements are commonly used in dietary supplements for stress management, cognitive enhancement, and overall health and well-being.
Salidroside benefits
As an adaptogen, salidroside helps the body adapt to various forms of stress by modulating the HPA axis, mitigating the negative effects of chronic stress. Salidroside’s potent antioxidant and anti-inflammatory properties may protect cells and tissues from damage. Furthermore, salidroside has demonstrated cardiovascular support by improving endothelial function, managing blood pressure, and inhibiting arterial stiffening, potentially reducing the risk of compromised heart health. These versatile applications make salidroside a valuable supplement for overall health and well-being. Ongoing research studies continue to examine its therapeutic effects across stress, vascular, and cellular health contexts.
Mitigate stress
By helping regulate the body’s stress response system by modulating the hypothalamic-pituitary-adrenal (HPA) axis. This can effectively mitigate the detrimental effects of chronic stress, including increased inflammation and oxidative stress, thereby supporting overall health and well-being.
Cardiovascular health
Emerging research indicates that salidroside may also offer cardiovascular benefits. Its effects on endothelial cells and blood vessels are relevant to vascular function, with cardiovascular research often focusing on vascular endothelial growth factor and hypoxia-inducible factor in this signaling context. The compound has been shown to improve endothelial function, help manage blood pressure, and inhibit arterial stiffening. These actions can help reduce the risk of cardiovascular compromise, making salidroside a promising dietary supplement for supporting heart health. This has also driven interest in promoting angiogenesis in ischemic settings.
Antioxidant & anti-inflammatory effects
Salidroside also exhibits potent antioxidant and anti-inflammatory properties, which may help limit reactive oxygen species-related damage and support cell survival. These actions help protect cells and tissues from the damaging effects of oxidative stress and inflammation, which are implicated in various health conditions. By providing broader protective effects against oxidative stress, salidroside is a valuable compound for supporting overall health.
How can salidroside be obtained?
Salidroside, the bioactive compound found in Rhodiola rosea, can also be found in Rhodiola crenulata and other Rhodiola species with distinct phytochemical profiles. The primary natural source is the extraction of salidroside from the roots of Rhodiola rosea using techniques such as solvent or supercritical fluid extraction. To increase concentration and ensure consistent quality, manufacturers often produce standardized Rhodiola extracts rich in salidroside. However, species choice matters because active components vary, and Rhodiola crenulata differs from Rhodiola rosea in its active compound composition. Additionally, salidroside can be synthesized in a laboratory setting, enabling the production of pure, pharmaceutical-grade salidroside. Advances in biotechnology have also enabled the production of salidroside through microbial fermentation using genetically engineered bacterial or yeast strains. In vitro cultures and fermentation are also used to enhance salidroside production while improving consistency. Molecular weight and standardization are also important for quality control in supplement applications. Regardless of the source, the goal is to obtain a high-quality, consistent, and concentrated form of salidroside for use in supplements, functional foods, and other applications.
